KPV

Overview

Researchers in anti-inflammatory and gut-barrier biology can buy KPV research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone, with a molecular weight of 340.4 Da. Its small size and receptor-independent activity make it a notable research tool.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

KPV emerged from research dissecting which portions of alpha-MSH are responsible for its various biological activities. The C-terminal tripeptide retains anti-inflammatory activity even in melanocortin-receptor-knockout preclinical models, indicating a receptor-independent mechanism — distinct from larger alpha-MSH fragments such as Melanotan II which signal through MC1R/MC3R/MC4R/MC5R.

Mechanism of Action (Research Context)

Mechanism research investigates KPV’s direct intracellular modulation of NF-kappaB signalling — likely via inhibition of IKK-mediated phosphorylation cascades — and downstream suppression of pro-inflammatory cytokine transcription. The receptor-independent activity is a research-tool advantage in studies dissecting melanocortin-receptor-mediated vs receptor-independent anti-inflammatory pathways.

Research Applications

• NF-kappaB pathway modulation and IKK signalling research
• Intestinal epithelial barrier function and tight-junction studies
• IBD (inflammatory bowel disease) preclinical model investigation
• Receptor-independent vs MC1R/MC4R-mediated alpha-MSH signalling comparison
• Multi-compound research via KLOW Blend for combined regenerative + anti-inflammatory investigation

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

KPV tripeptide gut health research USA COA?

Advanced Peptide Science supplies KPV at 99%+ HPLC-verified purity with batch-specific COA available on request. Widely investigated in intestinal epithelial and IBD model research.

Buy KPV melanocortin anti-inflammatory peptide — receptor binding?

KPV (Lys-Pro-Val) is unusual in that its anti-inflammatory activity is independent of melanocortin receptor binding. It modulates NF-kappaB signalling directly, distinct from larger alpha-MSH fragments such as Melanotan II.

Is KPV approved for human use?

Advanced Peptide Science supplies KPV exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.