ARA-290

Overview

Researchers in neuroprotection and cytoprotective signalling can buy ARA-290 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. ARA-290 (also called cibinetide) is a synthetic 11-amino-acid peptide derived from helix B of erythropoietin (EPO), with a molecular weight of approximately 1200 Da. It is a selective innate repair receptor (IRR) agonist.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

ARA-290 was engineered to separate the tissue-protective signalling of EPO from its erythropoietic activity. The helix-B-derived 11-residue peptide binds the heteromeric innate repair receptor (composed of the EPO receptor and the common beta chain CD131) without binding the homodimeric EPO receptor responsible for erythropoiesis — isolating cytoprotection research from haematological confounders.

Mechanism of Action (Research Context)

Mechanism research investigates ARA-290’s selective binding at the innate repair receptor (IRR), a heteromeric complex of EPOR and CD131. Downstream signalling includes anti-inflammatory pathway modulation and neuroprotective cascades active in peripheral neuropathy models — distinct from JAK2/STAT5 erythropoiesis signalling activated by EPO at the homodimeric EPOR.

Research Applications

• Innate repair receptor (IRR) agonism pharmacology research
• Peripheral neuropathy preclinical model investigation
• Tissue cytoprotection independent of erythropoietic signalling
• Anti-inflammatory pathway research via IRR vs homodimeric EPOR comparison
• Comparative cytoprotection vs BPC-157 and TB-500

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

ARA-290 innate repair receptor neuropathy research USA?

Advanced Peptide Science supplies ARA-290 at 99%+ HPLC-verified purity for in vitro and in vivo neuroprotection and peripheral neuropathy preclinical model research. Batch COA available on request.

Buy ARA-290 EPO-derived peptide research COA?

ARA-290 is derived from helix B of erythropoietin but binds the heteromeric innate repair receptor (EPOR + CD131) rather than the homodimeric EPOR responsible for erythropoiesis. This receptor selectivity isolates cytoprotection research from haematological confounders.

Is ARA-290 approved for human use?

Advanced Peptide Science supplies ARA-290 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.

For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent.