Melanotan II

Overview

Researchers in melanocortin receptor pharmacology can buy Melanotan II research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. Melanotan II is a cyclic lactam analogue of alpha-MSH (sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) with a molecular weight of 1024.2 Da — a non-selective agonist at MC1R and MC4R receptors.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

Melanotan II was engineered from alpha-MSH by introducing a cyclic lactam constraint that stabilises the bioactive conformation and enhances receptor binding. The compound is a research tool for melanocortin receptor pharmacology and is the parent compound from which PT-141 (Bremelanotide) is derived via deacetylation.

Mechanism of Action (Research Context)

Mechanism research investigates Melanotan II non-selective agonism at the melanocortin receptor family (MC1R, MC3R, MC4R, MC5R) — Gs-coupled GPCRs with diverse downstream effects. MC1R activation drives skin pigmentation pathway research (melanogenesis); MC4R activation drives CNS pathway studies including appetite regulation and behavioural neuroscience.

Research Applications

• Non-selective melanocortin receptor agonism research
• MC1R-mediated skin pigmentation pathway mechanism studies
• MC4R-mediated CNS pathway research
• Melanotropic receptor subtype binding-profile studies
• Comparative research vs selective MC4R agonist PT-141

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy Melanotan II 10mg research peptide USA COA?

Advanced Peptide Science supplies Melanotan II at 99%+ HPLC-verified purity with batch-specific COA available on request.

MC1R agonist research peptide — Melanotan II selectivity?

Melanotan II is a non-selective melanocortin receptor agonist binding MC1R, MC3R, MC4R, and MC5R. Compare against PT-141 (Bremelanotide), the selective MC4R agonist derived from Melanotan II via deacetylation.

Is Melanotan II approved for human use?

Advanced Peptide Science supplies Melanotan II exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.