Tirzepatide

Overview

Researchers looking to buy Tirzepatide research peptide for incretin co-activation studies will find Advanced Peptide Science supplies this 39-amino-acid synthetic dual agonist at 99%+ HPLC-verified purity, with batch-specific analytical documentation. Tirzepatide simultaneously engages the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors and is the most advanced incretin-class compound in current preclinical investigation.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

Tirzepatide emerged from incretin-mimetic optimisation programmes investigating dual receptor co-agonism as an extension of mono-agonist GLP-1 research lineages including Semaglutide and Liraglutide. The 39-residue backbone is engineered from native GIP with GLP-1 receptor activity layered in through targeted substitutions; a C20 fatty-diacid moiety on Lys20 enables albumin binding and an extended pharmacokinetic profile in preclinical models.

Mechanism of Action (Research Context)

Mechanism of action research focuses on Tirzepatide’s simultaneous engagement of the GIP receptor (GIPR) and the GLP-1 receptor (GLP-1R), both class B G-protein-coupled receptors expressed on pancreatic beta cells, in CNS appetite-regulation centres, and on adipocytes. Receptor co-engagement is investigated for synergistic cAMP signalling, glucose-dependent insulin secretion, glucagon suppression, and central appetite-circuit modulation including the arcuate nucleus and dorsomedial hypothalamus.

Research Applications

• GIP and GLP-1 receptor pharmacology and co-agonism research
• Pancreatic beta-cell function preservation and incretin-mediated insulin secretion studies
• CNS appetite-regulation circuitry investigation in preclinical models
• Metabolic-syndrome multi-axis research comparing dual vs mono-agonist signalling
• Adipocyte signalling and lipid metabolism investigation

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Where to buy Tirzepatide research peptide in the USA with COA?

Advanced Peptide Science supplies Tirzepatide at 99%+ HPLC-verified purity with batch-specific Certificates of Analysis available on request at research@advancedpeptidescience.com. All compounds are shipped from the United States to qualified research laboratories.

What is the molecular weight of Tirzepatide?

Tirzepatide has a molecular weight of 4813.5 Da and comprises 39 amino acids with a C20 fatty-diacid modification on lysine 20 enabling albumin binding.

Is Tirzepatide approved for human use?

Advanced Peptide Science supplies Tirzepatide exclusively for in vitro and in vivo scientific research. Not approved by FDA for human use. Not for human consumption. For research use only.