5-Amino-1MQ

Overview

Researchers investigating NAD+ pathway and methylation balance can buy 5-Amino-1MQ research capsules from Advanced Peptide Science. 5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with a molecular weight of 174.2 Da, supplied in oral 50mg capsule format for in vitro and in vivo research applications.

Research Background

5-Amino-1MQ emerged from medicinal-chemistry programmes designing small-molecule NNMT inhibitors. NNMT catalyses the N-methylation of nicotinamide using SAM as the methyl donor — a reaction that depletes both nicotinamide (a NAD+ precursor) and the methylation pool. Pharmacological NNMT inhibition is investigated for its effects on adipose tissue metabolism, energy expenditure, and methylation-dependent signalling.

Mechanism of Action (Research Context)

Mechanism research investigates 5-Amino-1MQ competitive inhibition at the NNMT active site, with downstream effects including elevated cellular NAD+ via preservation of the nicotinamide salvage pathway, altered SAM/SAH methylation balance, and reduced adipogenic differentiation in preclinical adipocyte models. AMPK pathway activation and mitochondrial-biogenesis signalling are areas of active investigation.

Research Applications

• NNMT inhibition pharmacology and competitive binding research
• NAD+ metabolism and nicotinamide salvage pathway studies
• Adipocyte differentiation and lipid-droplet formation research
• SAM/SAH methylation balance and epigenetic-marker research
• Energy expenditure and mitochondrial-biogenesis investigation

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

5-Amino-1MQ NNMT inhibitor capsules — research significance?

NNMT (nicotinamide N-methyltransferase) catalyses nicotinamide methylation, depleting NAD+ precursors and methylation pool. 5-Amino-1MQ inhibition is investigated for restored NAD+ availability and altered adipocyte differentiation pathways.

Buy 5-Amino-1MQ NAD precursor research — what format?

Advanced Peptide Science supplies 5-Amino-1MQ in oral 50mg capsule format in 30, 60, and 90 count bottles. Room-temperature storage. Batch-specific Certificates of Analysis available on request.

Is 5-Amino-1MQ approved for human use?

Advanced Peptide Science supplies 5-Amino-1MQ exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.

For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent.