5-Amino-1MQ

Overview

Researchers investigating NAD+ pathway and methylation balance can buy 5-Amino-1MQ research capsules from Advanced Peptide Science. 5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with a molecular weight of 174.2 Da, supplied in oral 50mg capsule format for in vitro and in vivo research applications.

Research Background

5-Amino-1MQ emerged from medicinal-chemistry programmes designing small-molecule NNMT inhibitors. NNMT catalyses the N-methylation of nicotinamide using SAM as the methyl donor — a reaction that depletes both nicotinamide (a NAD+ precursor) and the methylation pool. Pharmacological NNMT inhibition is investigated for its effects on adipose tissue metabolism, energy expenditure, and methylation-dependent signalling.

Mechanism of Action (Research Context)

Mechanism research investigates 5-Amino-1MQ competitive inhibition at the NNMT active site, with downstream effects including elevated cellular NAD+ via preservation of the nicotinamide salvage pathway, altered SAM/SAH methylation balance, and reduced adipogenic differentiation in preclinical adipocyte models. AMPK pathway activation and mitochondrial-biogenesis signalling are areas of active investigation.

Research Applications

• NNMT inhibition pharmacology and competitive binding research
• NAD+ metabolism and nicotinamide salvage pathway studies
• Adipocyte differentiation and lipid-droplet formation research
• SAM/SAH methylation balance and epigenetic-marker research
• Energy expenditure and mitochondrial-biogenesis investigation

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

5-Amino-1MQ NNMT inhibitor capsules — research significance?

NNMT (nicotinamide N-methyltransferase) catalyses nicotinamide methylation, depleting NAD+ precursors and methylation pool. 5-Amino-1MQ inhibition is investigated for restored NAD+ availability and altered adipocyte differentiation pathways.

Buy 5-Amino-1MQ NAD precursor research — what format?

Advanced Peptide Science supplies 5-Amino-1MQ in oral 50mg capsule format in 30, 60, and 90 count bottles. Room-temperature storage. Batch-specific Certificates of Analysis available on request.

Is 5-Amino-1MQ approved for human use?

Advanced Peptide Science supplies 5-Amino-1MQ exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.