SS-31

Overview

Researchers in mitochondrial bioenergetics can buy SS-31 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. SS-31 (also Elamipretide or Szeto-Schiller 31) is a mitochondria-targeted tetrapeptide with sequence D-Arg-2′,6′-Dmt-Lys-Phe-NH2 and a molecular weight of 638.8 Da.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

SS-31 was developed by Szeto and Schiller as a cell-permeable peptide that selectively partitions to the inner mitochondrial membrane via electrostatic interaction with cardiolipin — a phospholipid uniquely abundant on the inner mitochondrial membrane. The D-amino acid configuration confers protease resistance. Compare against the mitochondrial-derived peptide MOTS-c for distinct mitochondrial research mechanisms.

Mechanism of Action (Research Context)

Mechanism research investigates SS-31 association with cardiolipin on the inner mitochondrial membrane, with downstream effects on cristae structure maintenance, electron transport chain (Complex I-IV) coupling efficiency, ROS production reduction, and mitophagy pathway modulation. The cardiolipin-targeting mechanism is distinct from genomic or transcriptional mitochondrial research tools.

Research Applications

• Cardiolipin binding and inner mitochondrial membrane research
• Electron transport chain coupling efficiency studies
• Mitochondrial cristae structure maintenance investigation
• ROS reduction mechanism research
• Comparative mitochondrial research vs MOTS-c and Humanin

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy SS-31 Elamipretide mitochondrial peptide USA COA?

Advanced Peptide Science supplies SS-31 at 99%+ HPLC-verified purity with batch-specific COA available on request.

SS-31 cardiolipin mitochondria research — selective targeting?

SS-31 selectively partitions to the inner mitochondrial membrane via electrostatic interaction with cardiolipin (uniquely abundant on the inner membrane). This delivers the peptide to its site of action without genomic or transcriptional intervention.

Is SS-31 approved for human use?

Advanced Peptide Science supplies SS-31 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.