LL-37

Overview

Researchers in innate immunity and antimicrobial peptide research can buy LL-37 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. LL-37 is the C-terminal 37-amino-acid peptide derived from the human cathelicidin precursor protein hCAP18, with a molecular weight of 4493.3 Da and an alpha-helical secondary structure.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

LL-37 is one of the most-researched human antimicrobial peptides, representing the bioactive product of cathelicidin proteolytic processing. Its dual role as a direct-acting antimicrobial and as an immunomodulatory ligand makes it a versatile research tool spanning innate immunity, wound healing, and host defence preclinical model investigation.

Mechanism of Action (Research Context)

Mechanism research investigates LL-37 direct membrane disruption in bacterial models (via amphipathic alpha-helical insertion into bacterial membranes), FPRL1 receptor signalling in host immune cells, angiogenesis induction pathways, and epithelial wound healing models. The dual antimicrobial-plus-immunomodulatory profile is a major focus of comparative research.

Research Applications

• Innate immune pathway activation research
• Direct antimicrobial membrane disruption studies in bacterial models
• FPRL1 receptor signalling pharmacology research
• Angiogenesis induction pathway investigation
• Epithelial wound healing preclinical model research

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy LL-37 cathelicidin innate immunity research USA COA?

Advanced Peptide Science supplies LL-37 at 99%+ HPLC-verified purity with batch-specific COA available on request.

LL-37 antimicrobial wound healing research — mechanism?

LL-37 acts via two distinct mechanisms: direct membrane disruption (via alpha-helical insertion into bacterial membranes) and FPRL1 receptor signalling in host immune cells. The dual mechanism distinguishes it from classical antibiotic research tools.

Is LL-37 approved for human use?

Advanced Peptide Science supplies LL-37 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.

For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent.