FOXO4-DRI

Overview

Researchers in cellular senescence and senolytic compound research can buy FOXO4-DRI research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. FOXO4-DRI is a D-retro-inverso peptide (~4900 Da) engineered to disrupt the FOXO4-p53 protein-protein interaction that maintains senescent cell viability.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

FOXO4-DRI was reported by Baar et al. (Cell 2017) as a proof-of-concept senolytic — a compound that selectively clears senescent cells. The D-retro-inverso configuration (all amino acids in D-stereochemistry, sequence reversed) confers extreme protease resistance and is a research-tool design pattern for peptide-based protein-protein-interaction inhibitors.

Mechanism of Action (Research Context)

Mechanism research investigates FOXO4-DRI sequestration of p53 from FOXO4 in senescent cells, with downstream restoration of p53-mediated apoptotic signalling. Senescent cells exhibit elevated FOXO4 expression that sequesters p53 and inhibits the normal apoptotic clearance pathway — FOXO4-DRI disruption of this interaction selectively triggers apoptosis in senescent vs non-senescent populations.

Research Applications

• FOXO4-p53 protein-protein interaction pharmacology research
• Senescent cell clearance mechanism studies
• Apoptosis pathway restoration in senescent fibroblast models
• Senolytic compound comparative preclinical research
• D-retro-inverso peptide-design methodology research tool

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy FOXO4-DRI senolytic research peptide USA COA?

Advanced Peptide Science supplies FOXO4-DRI at 99%+ HPLC-verified purity with batch-specific COA available on request.

FOXO4 p53 apoptosis senescent cell research — mechanism?

Senescent cells express elevated FOXO4 which sequesters p53 and blocks normal apoptotic clearance. FOXO4-DRI displaces p53 from FOXO4, restoring p53-mediated apoptotic signalling selectively in senescent cells (per Baar et al. 2017).

Is FOXO4-DRI approved for human use?

Advanced Peptide Science supplies FOXO4-DRI exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.