PT-141

Overview

Researchers in selective melanocortin-receptor pharmacology can buy PT-141 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. PT-141 (also called Bremelanotide) is a cyclic heptapeptide (sequence cyclo[Nle-Asp-His-D-Phe-Arg-Trp-Lys]-OH, MW 1025.2 Da) derived from Melanotan II via N-terminal deacetylation.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

PT-141 was developed to retain MC4R agonism while reducing MC1R activity relative to its parent compound Melanotan II. The reduction in MC1R activity is research-relevant for separating CNS-mediated MC4R effects from peripheral skin-pigmentation MC1R effects in preclinical studies. The compound is a refined research tool for MC4R-selective pharmacology.

Mechanism of Action (Research Context)

Mechanism research investigates PT-141 selective agonism at MC4R (a Gs-coupled GPCR expressed in CNS appetite-regulation centres and behavioural neuroscience nuclei) with reduced binding at MC1R. Downstream pathways include cAMP signalling and CNS-mediated behavioural research endpoints distinct from melanogenic pathways.

Research Applications

• Selective MC4R receptor pharmacology research
• CNS melanocortin signalling investigation
• Sexual behaviour neuroscience preclinical model research
• MC4R vs MC1R receptor subtype selectivity studies
• Comparative research vs non-selective Melanotan II

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy PT-141 Bremelanotide research peptide USA COA?

Advanced Peptide Science supplies PT-141 at 99%+ HPLC-verified purity with batch-specific COA available on request.

PT-141 MC4R selective agonist research — how does it differ from Melanotan II?

PT-141 retains MC4R agonism but has reduced MC1R activity vs the parent Melanotan II, due to N-terminal deacetylation. The selectivity profile is useful for isolating CNS MC4R effects from peripheral MC1R effects.

Is PT-141 approved for human use?

Advanced Peptide Science supplies PT-141 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.

For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent.