PT-141

Overview

Researchers in selective melanocortin-receptor pharmacology can buy PT-141 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. PT-141 (also called Bremelanotide) is a cyclic heptapeptide (sequence cyclo[Nle-Asp-His-D-Phe-Arg-Trp-Lys]-OH, MW 1025.2 Da) derived from Melanotan II via N-terminal deacetylation.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

PT-141 was developed to retain MC4R agonism while reducing MC1R activity relative to its parent compound Melanotan II. The reduction in MC1R activity is research-relevant for separating CNS-mediated MC4R effects from peripheral skin-pigmentation MC1R effects in preclinical studies. The compound is a refined research tool for MC4R-selective pharmacology.

Mechanism of Action (Research Context)

Mechanism research investigates PT-141 selective agonism at MC4R (a Gs-coupled GPCR expressed in CNS appetite-regulation centres and behavioural neuroscience nuclei) with reduced binding at MC1R. Downstream pathways include cAMP signalling and CNS-mediated behavioural research endpoints distinct from melanogenic pathways.

Research Applications

• Selective MC4R receptor pharmacology research
• CNS melanocortin signalling investigation
• Sexual behaviour neuroscience preclinical model research
• MC4R vs MC1R receptor subtype selectivity studies
• Comparative research vs non-selective Melanotan II

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy PT-141 Bremelanotide research peptide USA COA?

Advanced Peptide Science supplies PT-141 at 99%+ HPLC-verified purity with batch-specific COA available on request.

PT-141 MC4R selective agonist research — how does it differ from Melanotan II?

PT-141 retains MC4R agonism but has reduced MC1R activity vs the parent Melanotan II, due to N-terminal deacetylation. The selectivity profile is useful for isolating CNS MC4R effects from peripheral MC1R effects.

Is PT-141 approved for human use?

Advanced Peptide Science supplies PT-141 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.