Humanin

Overview

Researchers in mitochondrial-derived peptide neuroprotection can buy Humanin research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. Humanin is a 21-amino-acid peptide with a molecular weight of 2702.1 Da, encoded within the 16S rRNA mitochondrial gene — a second example (alongside MOTS-c) of a mitochondrial-derived peptide.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

Humanin was the first mitochondrial-derived peptide discovered, initially identified for its neuroprotective activity in models of Alzheimer’s-related neurodegeneration. Like MOTS-c, it represents a class of small peptides encoded within mitochondrial DNA that signal beyond the mitochondrion proper, expanding the research framework of mitochondrial biology.

Mechanism of Action (Research Context)

Mechanism research investigates Humanin inhibition of BAX (Bcl-2-associated X protein) translocation to the mitochondrial outer membrane, preventing cytochrome c release and the intrinsic apoptosis pathway. Additional research examines Humanin interaction with the IGF-1 receptor and downstream survival signalling, plus age-related biomarker associations in metabolic and neurological models.

Research Applications

• Mitochondrial-derived peptide signalling research
• BAX-dependent apoptosis inhibition mechanism studies
• IGF-1 receptor interaction pharmacology research
• Neuronal survival pathway investigation
• Comparative research with MOTS-c and SS-31

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy Humanin mitochondrial neuroprotective peptide USA COA?

Advanced Peptide Science supplies Humanin at 99%+ HPLC-verified purity with batch-specific COA available on request.

Humanin MOTS-c comparison research?

Both are mitochondrial-derived peptides. Humanin (21 amino acids, 2702.1 Da, 16S rRNA-encoded) is investigated for BAX-dependent apoptosis inhibition and neuronal survival; MOTS-c (16 amino acids, 2174.5 Da, 12S rRNA-encoded) is investigated for AMPK activation and metabolic flexibility.

Is Humanin approved for human use?

Advanced Peptide Science supplies Humanin exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.