LL-37

Overview

Researchers in innate immunity and antimicrobial peptide research can buy LL-37 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. LL-37 is the C-terminal 37-amino-acid peptide derived from the human cathelicidin precursor protein hCAP18, with a molecular weight of 4493.3 Da and an alpha-helical secondary structure.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

LL-37 is one of the most-researched human antimicrobial peptides, representing the bioactive product of cathelicidin proteolytic processing. Its dual role as a direct-acting antimicrobial and as an immunomodulatory ligand makes it a versatile research tool spanning innate immunity, wound healing, and host defence preclinical model investigation.

Mechanism of Action (Research Context)

Mechanism research investigates LL-37 direct membrane disruption in bacterial models (via amphipathic alpha-helical insertion into bacterial membranes), FPRL1 receptor signalling in host immune cells, angiogenesis induction pathways, and epithelial wound healing models. The dual antimicrobial-plus-immunomodulatory profile is a major focus of comparative research.

Research Applications

• Innate immune pathway activation research
• Direct antimicrobial membrane disruption studies in bacterial models
• FPRL1 receptor signalling pharmacology research
• Angiogenesis induction pathway investigation
• Epithelial wound healing preclinical model research

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy LL-37 cathelicidin innate immunity research USA COA?

Advanced Peptide Science supplies LL-37 at 99%+ HPLC-verified purity with batch-specific COA available on request.

LL-37 antimicrobial wound healing research — mechanism?

LL-37 acts via two distinct mechanisms: direct membrane disruption (via alpha-helical insertion into bacterial membranes) and FPRL1 receptor signalling in host immune cells. The dual mechanism distinguishes it from classical antibiotic research tools.

Is LL-37 approved for human use?

Advanced Peptide Science supplies LL-37 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.