ARA-290

Overview

Researchers in neuroprotection and cytoprotective signalling can buy ARA-290 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. ARA-290 (also called cibinetide) is a synthetic 11-amino-acid peptide derived from helix B of erythropoietin (EPO), with a molecular weight of approximately 1200 Da. It is a selective innate repair receptor (IRR) agonist.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

ARA-290 was engineered to separate the tissue-protective signalling of EPO from its erythropoietic activity. The helix-B-derived 11-residue peptide binds the heteromeric innate repair receptor (composed of the EPO receptor and the common beta chain CD131) without binding the homodimeric EPO receptor responsible for erythropoiesis — isolating cytoprotection research from haematological confounders.

Mechanism of Action (Research Context)

Mechanism research investigates ARA-290’s selective binding at the innate repair receptor (IRR), a heteromeric complex of EPOR and CD131. Downstream signalling includes anti-inflammatory pathway modulation and neuroprotective cascades active in peripheral neuropathy models — distinct from JAK2/STAT5 erythropoiesis signalling activated by EPO at the homodimeric EPOR.

Research Applications

• Innate repair receptor (IRR) agonism pharmacology research
• Peripheral neuropathy preclinical model investigation
• Tissue cytoprotection independent of erythropoietic signalling
• Anti-inflammatory pathway research via IRR vs homodimeric EPOR comparison
• Comparative cytoprotection vs BPC-157 and TB-500

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

ARA-290 innate repair receptor neuropathy research USA?

Advanced Peptide Science supplies ARA-290 at 99%+ HPLC-verified purity for in vitro and in vivo neuroprotection and peripheral neuropathy preclinical model research. Batch COA available on request.

Buy ARA-290 EPO-derived peptide research COA?

ARA-290 is derived from helix B of erythropoietin but binds the heteromeric innate repair receptor (EPOR + CD131) rather than the homodimeric EPOR responsible for erythropoiesis. This receptor selectivity isolates cytoprotection research from haematological confounders.

Is ARA-290 approved for human use?

Advanced Peptide Science supplies ARA-290 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.