Liraglutide

Overview

Researchers can buy Liraglutide research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity for first-generation GLP-1 receptor pharmacology research. Liraglutide is a 31-amino-acid GLP-1 analogue with 97% structural homology to native human GLP-1 and a 3751.2 Da molecular weight — widely used as a comparative standard in GLP-1 receptor research.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

Liraglutide is the prototype long-acting GLP-1 analogue, predating second-generation compounds such as Semaglutide. The C16 fatty-acid attachment via Lys26 enables non-covalent albumin binding, extending the preclinical half-life relative to native GLP-1 (which has a half-life of approximately 2 minutes). The compound is widely used as a comparator in GLP-1 receptor research lineages.

Mechanism of Action (Research Context)

Mechanism research investigates Liraglutide binding at the GLP-1 receptor (GLP-1R) and downstream Gs-coupled cAMP signalling driving glucose-dependent insulin secretion from pancreatic beta cells, glucagon suppression, and delayed gastric emptying in preclinical models. CNS appetite-regulation circuitry investigation includes GLP-1R-expressing neurons in the arcuate nucleus and brainstem.

Research Applications

• GLP-1 receptor binding affinity and downstream signalling research
• Glucose-dependent insulin secretion and beta-cell function studies
• First-generation vs second-generation GLP-1 analogue comparison research
• Preclinical pharmacokinetics with albumin-binding fatty-acid modification
• Comparator standard for Semaglutide and Tirzepatide investigations

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy liraglutide GLP-1 research peptide USA COA?

Advanced Peptide Science supplies Liraglutide at 99%+ HPLC-verified purity with batch-specific COA available on request at research@advancedpeptidescience.com.

Liraglutide vs Semaglutide research comparison — what changed?

Both are GLP-1 receptor agonists. Liraglutide (3751.2 Da, C16 fatty acid) has higher native GLP-1 homology (97%) but a shorter preclinical half-life than Semaglutide (4113.6 Da, C18 fatty diacid, 94% homology, Aib8 substitution for DPP-4 resistance).

Is Liraglutide approved for human use?

Advanced Peptide Science supplies Liraglutide exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.