MOTS-c

Overview

Researchers in mitochondrial-derived peptides can buy MOTS-c research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. MOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) is a 16-amino-acid peptide with a molecular weight of 2174.5 Da, encoded within the 12S rRNA mitochondrial gene.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

MOTS-c was discovered as one of the first known mitochondrial-derived peptides, encoded within a small open reading frame of the 12S rRNA gene. Under metabolic stress (e.g., during exercise or nutrient deprivation), MOTS-c translocates from mitochondria to the nucleus, where it influences nuclear gene expression — a research-tool example of mitochondrial-to-nuclear retrograde signalling. Other mitochondrial-derived peptides include Humanin.

Mechanism of Action (Research Context)

Mechanism research investigates MOTS-c activation of AMPK (AMP-activated protein kinase) in skeletal muscle and other metabolically active tissues, with downstream effects on glucose uptake, mitochondrial biogenesis, and insulin sensitivity. The nuclear translocation under stress is investigated for transcriptional effects mimicking exercise adaptations.

Research Applications

• AMPK pathway activation pharmacology research
• Metabolic flexibility in skeletal muscle model research
• Exercise response mimicry mechanism investigation
• Insulin sensitivity pathway studies
• Mitochondrial-to-nuclear retrograde signalling research

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy MOTS-c mitochondrial peptide AMPK research USA COA?

Advanced Peptide Science supplies MOTS-c at 99%+ HPLC-verified purity with batch-specific COA available on request.

MOTS-c exercise mimetic longevity research — mechanism?

MOTS-c activates AMPK and translocates to the nucleus under metabolic stress, where it influences gene expression patterns that overlap with those induced by exercise — a research tool for investigating exercise-mimetic transcriptional adaptations.

Is MOTS-c approved for human use?

Advanced Peptide Science supplies MOTS-c exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.