Dihexa

Overview

Researchers in synaptogenesis and neurotrophic peptide research can buy Dihexa research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic-amide) is a small-molecule angiotensin IV analogue with a molecular weight of 474.6 Da, developed at Washington State University.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

Dihexa was engineered as an orally bioavailable, blood-brain-barrier-permeable analogue of angiotensin IV with enhanced synaptogenic activity. Its small size (474.6 Da) and stable structure distinguish it from larger neuroactive peptides such as Cerebrolysin and other neurotrophic research compounds.

Mechanism of Action (Research Context)

Mechanism research investigates Dihexa potentiation of the hepatocyte growth factor (HGF) / c-Met receptor cascade, which is implicated in synaptogenesis stimulation independent of the BDNF/TrkB pathway. Research also examines interactions with AT4 and IRAP receptors in CNS preclinical models.

Research Applications

• HGF/MET receptor cascade potentiation pharmacology research
• Synaptogenesis stimulation studies in cortical and hippocampal preclinical models
• BDNF-independent cognitive mechanism research
• AT4 / IRAP receptor pharmacology investigation
• Comparative synaptogenesis research vs neurotrophic mixtures such as Cerebrolysin

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy Dihexa HGF MET synaptogenesis research peptide USA?

Advanced Peptide Science supplies Dihexa at 99%+ HPLC-verified purity with batch-specific COA available on request.

Dihexa cognitive peptide — mechanism distinct from BDNF?

Dihexa potentiates the HGF/c-Met receptor cascade, a synaptogenesis pathway investigated independently of BDNF/TrkB signalling. This makes Dihexa a useful research tool for dissecting BDNF-mediated vs HGF-mediated synaptogenic mechanisms.

Is Dihexa approved for human use?

Advanced Peptide Science supplies Dihexa exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.