PE-22-28

Overview

Researchers in TREK-1 channel pharmacology and rapid-onset antidepressant mechanism research can buy PE-22-28 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. PE-22-28 is a synthetic analogue of spadin derived from the sortilin propeptide, with a molecular weight of approximately 800 Da.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

Spadin is a naturally occurring fragment cleaved from the sortilin propeptide that selectively blocks TREK-1 (TWIK-related potassium channel-1). PE-22-28 was engineered as a stabilised synthetic analogue retaining the TREK-1-blocking activity for research applications. TREK-1 is a two-pore-domain background potassium channel implicated in stress-related neurobiology.

Mechanism of Action (Research Context)

Mechanism research investigates PE-22-28 selective blockade of the TREK-1 channel, leading to neuronal depolarisation in TREK-1-expressing neurons (notably in the dorsal raphe nucleus). The mechanism is investigated as a fast-onset antidepressant target distinct from monoamine reuptake inhibition (the SSRI mechanism), with potential downstream effects on serotonergic neuron firing rates.

Research Applications

• TREK-1 potassium channel pharmacology and selective blockade research
• Rapid-onset antidepressant mechanism investigation distinct from SSRIs
• Sortilin propeptide / spadin signalling pathway research
• Stress-related neurobiology preclinical model studies
• Two-pore-domain potassium channel selective-modulator comparative research

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy PE-22-28 TREK-1 potassium channel research USA?

Advanced Peptide Science supplies PE-22-28 at 99%+ HPLC-verified purity with batch-specific COA available on request.

Spadin analogue fast-acting antidepressant research — mechanism?

PE-22-28 selectively blocks TREK-1, depolarising TREK-1-expressing neurons including serotonergic neurons of the dorsal raphe nucleus. This mechanism is distinct from SSRIs (which act on the monoamine reuptake transporter SERT).

Is PE-22-28 approved for human use?

Advanced Peptide Science supplies PE-22-28 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.