IGF-1 LR3

Overview

Researchers in IGF-1 receptor pharmacology and myosatellite cell biology can buy IGF-1 LR3 research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. IGF-1 LR3 (Long R3 IGF-1) is an 83-amino-acid analogue of native insulin-like growth factor 1 (which is 70 residues), engineered with N-terminal extension and substitution to extend preclinical half-life from 12-15 minutes (native) to approximately 20-30 hours.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

IGF-1 LR3 was engineered by adding a 13-residue Arg-Glu3 extension at the N-terminus and substituting Glu3 with Arg in the native IGF-1 sequence. These modifications dramatically reduce binding affinity to IGF-binding proteins (IGFBP-1 through IGFBP-6) which normally sequester IGF-1 in circulation, leaving more free IGF-1 LR3 available to bind the IGF-1 receptor.

Mechanism of Action (Research Context)

Mechanism research investigates IGF-1 LR3 binding at the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase driving downstream PI3K/Akt and MAPK signalling cascades. Research applications include myosatellite cell proliferation, anabolic signalling pathway investigation, and IGF-1R receptor activation kinetics with reduced IGFBP sequestration confounder.

Research Applications

• IGF-1 receptor activation kinetics research
• Myosatellite cell proliferation model studies
• PI3K/Akt and MAPK anabolic signalling pathway research
• IGFBP-independent IGF-1R agonism investigation
• Comparative research vs native IGF-1 in preclinical anabolic models

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy IGF-1 LR3 long arginine research peptide USA COA?

Advanced Peptide Science supplies IGF-1 LR3 at 99%+ HPLC-verified purity with batch-specific COA available on request.

IGF-1 LR3 anabolic signalling research peptide — what is the LR3 modification?

“LR3” denotes the Long Arg3 modification: a 13-residue Arg-Glu3 N-terminal extension plus Glu3Arg substitution. These reduce IGFBP affinity, extending half-life from 12-15 minutes (native IGF-1) to approximately 20-30 hours.

Is IGF-1 LR3 approved for human use?

Advanced Peptide Science supplies IGF-1 LR3 exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.