Sermorelin

Overview

Researchers can buy Sermorelin research peptide from Advanced Peptide Science at 99%+ HPLC-verified purity. Sermorelin (GHRH 1-29) is a 29-amino-acid GHRH analogue representing the biologically active N-terminal fragment of native human growth hormone-releasing hormone, with a molecular weight of 3357.9 Da. It is the first synthetic GHRH analogue developed for research.

Bacteriostatic Water (BAC Water) 30ml is required for reconstitution of this lyophilized compound. Available separately: Bacteriostatic Water 30ml.

Research Background

Sermorelin was developed as the minimal biologically active fragment of native human GHRH (which is 44 amino acids). The 29-residue N-terminal fragment retains GHRH-receptor agonism while simplifying synthesis. Sermorelin has shorter half-life than modified GHRH analogues such as CJC-1295 (DAC-modified) and Tesamorelin (trans-3-hexenoic acid modified), making it useful for pulsatile GH-axis research where short receptor occupancy is desired.

Mechanism of Action (Research Context)

Mechanism research investigates Sermorelin binding at the GHRH receptor (GHRHR), a class B GPCR on pituitary somatotrophs coupled to Gs/cAMP signalling. Downstream pathways include GH gene transcription, baseline GH secretion, and pituitary somatotroph maintenance. Comparative research against modified GHRH analogues focuses on receptor occupancy kinetics and pulsatile vs sustained activation profiles.

Research Applications

• GHRH receptor occupancy kinetics and pulsatile activation research
• Pituitary somatotroph function and maintenance studies
• Comparative GHRH-analogue research vs CJC-1295 and Tesamorelin
• Combined GHRH/GHRP research with GHRP-6
• GH-axis baseline vs amplified secretion model research

Compound Specifications

Quality Assurance

Each batch is independently verified by third-party analytical laboratories. Certificates of Analysis confirming ≥99% purity via HPLC are available on request at research@advancedpeptidescience.com.

Research Use Only. For Research Use Only. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing you confirm research-only intent. These products have not been evaluated by the FDA.

Frequently Asked Questions

Buy Sermorelin GHRH 1-29 research peptide USA COA?

Advanced Peptide Science supplies Sermorelin at 99%+ HPLC-verified purity with batch-specific COA available on request.

Sermorelin vs CJC-1295 research comparison?

Both are GHRH analogues. Sermorelin is the unmodified 29-residue N-terminal fragment with short half-life. CJC-1295 (in the CJC-1295 + Ipamorelin Blend) carries a DAC modification enabling albumin binding and extended half-life — useful for sustained vs pulsatile GHRH-receptor research.

Is Sermorelin approved for human use?

Advanced Peptide Science supplies Sermorelin exclusively for in vitro and in vivo scientific research. Not for human consumption. Research use only.